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On 7 March 2021, during coordinated operations led by the police and military in the Batangas, Cavite, Laguna and Rizal provinces surrounding Metro Manila, five human rights defenders were among those killed and four human rights defenders were arrested. Human rights defenders Emanuel Asucion, Melvin Dasigao, Mark Lee Coros Bacasno, Chai Lemita-Evangelista and Ariel Evangelista were among those killed, whilst human rights defenders Nimfa Lanzanas, Esteban Mendoza, Eugene Eugenio and Elizabeth Camoral were arrested during the raids.

On 31 August 2021, the European Court of Human Rights (ECHR) ruled on the case Estemirova v. Russia concerning the murder of prominent woman human rights defender Natalia Estemirova on 15 July 2009. The Court ruled that Russia failed to investigate the murder of Natalia Estemirova properly, yet did not find that the Russian authorities are directly responsible for her kidnapping and killing.

On 5 and 6 of March 2022 three human rights defenders, Youseif Yagoub Ahmed, Mohamed Ibrahim Yahya and Mohamed Eldai Musa were killed in Jabal Moon, West Darfur by armed militia while they were doing an assessment on the human rights and humanitarian situation in West Darfur. The three human rights defenders were members of Darfur Human Rights Monitors network, a network of human rights monitoring groups in the five states of Darfur.

The Association of Indigenous Councils of Northern Cauca (ACIN) has reported a new series of armed attacks and threats in Nasa indigenous territory in the department of Cauca. During the last weeks of January 2022, armed attacks by alleged outlawed groups have caused the death of three human rights defenders and kiwe thegnas (indigenous guards), Breiner David Cucuñame López, Guillermo Chicame Ipia and José Albeiro Camayo Güetio, in the Nasa Las Delicias indigenous reservation in the municipality of Buenos Aires.

On 19 January 2021, LGBTIQ+ rights defender Paschal Raymond was brutally killed by unknown assailants in Dar es Salaam, Tanzania.

On 20 June 2022, human rights defenders and priests Joaquín César Mora Salazar and Javier Campos Morales were shot dead by gunmen, along with another person inside a church in the indigenous community of Cerocahui, Chihuahua state.

On 8 March 2022, land rights defender and member of the grass-roots movement Abahlali baseMjondolo, Ayanda Ngila, was shot and killed by four armed men. At the time of the shooting, the human rights defender had been working on repairing an irrigation pipe in the eKhenana community garden. The gunmen fled the scene through the river. A suspect has been detained for questioning by the Cato police.

On 15 September 2021 around 5:30 p.m., human rights defender Juan Macababbad was shot dead outside his residence in Surallah town, South Cotabato by two unidentified individuals. After the attack, the human rights defender was taken to Javelosa Hospital where he was pronounced dead.

On 10 March 2021, Jaseb Hatteb, father of human rights defender Ali Jaseb Hatteb, was assassinated by an unknown militant in the city of Amarah. The family of the human rights defender believes that Jaseb Hatteb was assassinated as result of his efforts to find his son Ali Jaseb Hatteb who was abducted and disappeared on 8 October 2019.

On 7 March 2021, during coordinated operations led by the police and military in the Batangas, Cavite, Laguna and Rizal provinces surrounding Metro Manila, five human rights defenders were among those killed and four human rights defenders were arrested. Human rights defenders Emanuel Asucion, Melvin Dasigao, Mark Lee Coros Bacasno, Chai Lemita-Evangelista and Ariel Evangelista were among those killed, whilst human rights defenders Nimfa Lanzanas, Esteban Mendoza, Eugene Eugenio and Elizabeth Camoral were arrested during the raids.

On 7 March 2021, during coordinated operations led by the police and military in the Batangas, Cavite, Laguna and Rizal provinces surrounding Metro Manila, five human rights defenders were among those killed and four human rights defenders were arrested. Human rights defenders Emanuel Asucion, Melvin Dasigao, Mark Lee Coros Bacasno, Chai Lemita-Evangelista and Ariel Evangelista were among those killed, whilst human rights defenders Nimfa Lanzanas, Esteban Mendoza, Eugene Eugenio and Elizabeth Camoral were arrested during the raids.