On 25 May 2016, transgender human rights defender Alesha died from six gunshot wounds received three days earlier, on 22 May 2016, in front of Asia Plaza in Peshawar, Khyber Pakhtunkhwa province. Members of the Trans Action Alliance have previously faced persecution and harassment in connection with their human rights work. Alesha became the fifth member of the Alliance to have been attacked this year. In total, approximately 45 transgender people have been killed and 300 have suffered various forms of violence in the last two years in the Khyber Pakhtunkhwa province.
On 4 March 2017, prominent lawyer and human rights defender Muhammad Jan Gigyani was murdered by two armed, unknown assailants in Shabqadar, a small town located near the Afghan border, in Khyber Pakhtunkhwa.